sábado, 4 de abril de 2009

Ômega 3 reduz câncer de próstata

Atenção aos aficionados por produtos naturais e aos que desacreditam deles: consumir a partir de 500mg de ácidos graxos ômega 3 na dieta ou suplementos reduz a incidência de câncer de próstata e de câncer de próstata avançado. Foi o que um estudo publicado numa das mais prestigiadas revistas de cancerologia do mundo concluiu. A notícia completa segue abaixo:

NEW YORK (Reuters Health) Mar 25 - Results of a case-control study suggest that a high intake of long-chain omega-3 fatty acids protects against advanced prostate cancer, and this effect may be modified by a genetic variant of COX-2, a key enzyme in fatty acid metabolism and inflammation.

"Previous research has shown protection (by omega-3 fatty acids) against prostate cancer, but this is one of the first studies to show protection against advanced prostate cancer and interaction with COX-2," Dr. John S. Witte of the University of California, San Francisco noted in a statement from the American Association for Cancer Research (AACR)

Dr. Witte and colleagues studied 466 men diagnosed with aggressive prostate cancer and 478 age- and ethnicity-matched controls. They assessed diet using a food frequency questionnaire and genotyped the men for nine COX-2 single nucleotide polymorphisms.

In an online issue of the AACR journal Clinical Cancer Research, the researchers report that increasing intake of long-chain omega-3 fatty acids was strongly associated with a decreased risk of aggressive prostate cancer.

Men in the highest quartiles of long chain omega-3 fatty acid intake had a 63 percent reduced risk of aggressive prostate cancer (odds ratio, 0.37) compared to men in the lowest quartile.

"Importantly," Dr. Witte and colleagues say, this protective effect was even stronger in men who carried the COX-2 single nucleotide polymorphism rs4647310, a risk factor for prostate cancer.

Specifically, men with low intake of long-chain omega-3 fatty acids and this particular variant had a more than fivefold increased risk of advanced prostate cancer (odds ratio, 5.49), whereas men with high intake of omega-3 fatty acids had a substantially reduced risk, even if they carried the COX-2 rs4647310 variant.

In other words, the increased risk of prostate cancer associated with the COX-2 rs4647310 variant was "essentially reversed by increasing omega-3 fatty acid intake by a half a gram per day," Dr. Witte said.

"If you want to think of the overall inverse association in terms of fish, where omega-3 fatty acids are commonly derived, the strongest effect was seen from eating dark fish such as salmon one or more times per week," he added.

Clin Cancer Res 2009;15:7.



Nenhum comentário:

Postar um comentário

Clique aqui!

2015 A.C. Camargo academic journals acesso aberto adverse drug reactions alergia alquilantes alto custo ambiente ambientes virtuais analgésicos anomalias vasculares anti-eméticos anti-helmínticos anti-histamínico antianêmicos antiangiogênico anticâncer anticoagulantes antifúngicos antiprotozoários antivirais artemisinina arXiv asma asthma atopia atualização aula aulas auto-arquivamento avastin avermectina bevacizumab biologicals bioRxiv Blogger brain tumor bundler cancer cancerologia pediátrica Carlos Chagas carne vermelha cauterização Ceará CERN child chronic fatigue syndrome ciência ciência brasileira ciências biológicas e da saúde cientistas influentes cirurgia CLI Command Line Tools conselho internacional crime virtual CT scans Curtis Harris darbopoietina dermatite desenvolvedor diabetes dieta disautonomia dislipidemias doença renal doenças cardíacas doenças parasitárias dor DPOC eczema editoras predatórias efeitos adversos eficácia ensino e pesquisa eritropoietina erlotinib ESA escleroterapia estatinas esteróides estilo de vida exercícios F1000Research farmacogenética farmacologia fatores de crescimento fibromialgia Figshare Fisiologia e Medicina fitness flu FMJ Fortaleza fosfoetanolamina fraude acadêmica fraude eletrônica genetics GitHub glioblastoma gliomas Google Books Google mapas gordos green way Harald zur Hausen hemangiomas hemophagocytic lymphohistiocytosis High Sierra homebrew horário imagem immunology imunossupressores imunoterapia infecção urinária inibidores de ECA inibidores tirosina-quinase iniciação científica insulina irracionalismo ivermectina Jeffrey Beall Jekyll journal hijack Lectures lepra leucemia leukemia linfangiomas Mac OS Mac OS X macrophage activation syndrome magrinhas mal-formações March for Science Marcha pela Ciência medicina personalizada meta-análise Milton Santos modelos monoclonais monoclonal antibody mortalidade morte mudança Mulliken neuro-oncologia neuroblastoma neurology ngram viewer Nobel Nobel em Medicina ou Fisiologia novas drogas novos tratamentos obesidade ômega 3 open access open science OpenAIRE osteoporose Osvaldo Cruz package installer pediatria pediatric cancer pediatric tumors pediatrics peer review PeerJ personalized medicine PET/CT pharmacogenetics pharmacological treatment pharmacology plágio política de C&T posters postprints predatory publishers Preprints pressão arterial prevenção progressista projeto de pesquisa propranolol próstata publicação publicação científica publicações publication pubmed Python python 2 python 3 quimioterapia radiation radioterapia rapamycin rbenv recidiva regressão espontânea Regulação médica repository resposta resultados retrospectiva revisão por pares risco Ruby Satoshi Ömura Scholarly Open Access science ScienceNOW seguimento selênio self-archiving sequestro de periódico científico serotonina SIDA sildenafil slides sobrevida sulfa suplementos survival tacerva targeted therapy temozolamida temozolomide terapia alternativa tireóide tratamento tuberculose tumores cerebrais tumores pediátricos vaccine vacina venv via dourada via verde virtualenv virtualenvwrapper vitamina E vitaminas William C. Campbell Xcode Youyou Tu Zenodo

Postagens populares